Studying organ crosstalk leads to a deeper understanding of sepsis

Sepsis, a complex systemic response to infection leading to organ failure, is generally studied at the level of individual organs; this research has hinted at altered metabolic changes. A new study takes a two-pronged approach and investigates for the first time the metabolic changes across affected organs in a large animal model of sepsis and identifies both potential common and organ-specific metabolic alterations contributing to the disease process.